International Scleroderma Network (ISN)

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We are a full-service nonprofit and the world's #1 scleroderma site for patients and physicians alike.

What is Scleroderma?

Scleroderma is a rare, chronic autoimmune disease which afflicts an estimated 300,000 Americans, primarily females who are 30 to 50 years old at onset. The overall occurrence is 1 per 1,000 (.001% of the 310 million U.S. population) and the ratio of women to men is about four to one.

Scleroderma is both a rheumatic disease and a connective tissue disease. The term rheumatic disease refers to a group of conditions characterized by inflammation and/or pain in the muscles, joints, or fibrous tissue. A connective tissue disease is one that affects tissues such as skin, tendons, and cartilage. NIAMS.

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